报告题目： 微生物与免疫前沿论坛--Regulation of inflammation by Notch signaling components

报告人：胡小玉

报告人简介：

    2014年起担任清华大学免疫学研究所研究员、博士生导师。胡小玉毕业于北京大学医学部基础医学系，于美国康奈尔大学取得免疫学博士学位，并曾担任康奈尔医学院tenure track助理教授。她的主要研究领域是巨噬细胞活化与功能的调控及其在自身免疫病中的作用，目前已发表论文40余篇，被引用次数2800余次,H index = 27。多项研究成果发表在Nature Immunology和Immunity等免疫学国际期刊上。

报告内容简介：

   The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of inflammation and autoimmune disorders. Interestingly, the gene encoding the master transcription regulator of the Notch pathway, Rbpj, is among the recently identified new rheumatoid arthritis risk loci yet the functional significance of Notch-RBP-J signaling in pathogenesis of rheumatoid arthritis is unclear. During the past several years, we and others have described a key regulatory role of the Notch pathway in innate immune and inflammatory responses. Notch1-RBP-J axis promotes inflammatory macrophage polarization while a Notch target gene Hes1 dampens inflammation by attenuating macrophage chemokine production. Such regulatory patterns impose positive and negative checkpoints on inflammatory responses and may have potential implications for pathogenesis and therapy of autoimmune and inflammatory disorders such as rheumatoid arthritis.

组织单位：医学院           主持人：张庆镐

报告时间：2018.9.22   14:00-17:00

报告地点：医学院228会议室